Endocrine Abstracts

Introduction: Primary bilateral macronodular adrenal hyperplasia (PBMAH) is a rare entity. Up to 1/3 of patients with incidental bilateral adrenal nodules presents biochemical evidence of hypercortisolism responsible for obesity, diabetes mellitus (DM), arterial hypertension or dyslipidemia. Its insidious course and nonspecific signs explain the underdiagnosis of this entity.Objective: To describe the case of a patient with metabolic syndrome (MS) with h...

Introduction: : Adrenocortical carcinoma (ACC) is a rare tumor, often with an unfavorable prognosis. The management of ACC is challenging due to its low frequency and limited experience. The objective of this study was to describe the adverse events (AE) in patients diagnosed with ACC treated in the Divisions of Endocrinology and Oncology at the Ramón y Cajal University Hospital (Madrid, Spain) in the last seven years.Methods: Records of patients wi...

Introduction: Broncho-Pulmonary Neoplasms (BP-NENs) are rare neoplasms arising from neuroendocrine cells of the respiratory epithelium. Since previous studies in our lab have demonstrated the efficacy ofEverolimus, approved for BP-NENs treatment, and Dinaciclib, a Cyclins and CdKs inhibitor, on monolayer system we have investigated if a more complex tumour system could generate a change in drugs effects and cell resistance. Therefore, through the use of 3D culture model, we ha...

Background: Pancreatic Neuroendocrine Neoplasms (pNENs) are malignancies arising from the endocrine pancreas. Past in vitro studies have led to a better comprehension and characterization of this malignancy under several points of view. However, effective medical therapies are still not available, therefore, it is essential to continue studying this malignancy in order to identify a successful approach. Due to tumour complexity, techniques such as 3D cultures, able to...

Introduction: Multiple endocrine neoplasia type 1 syndrome (MEN1) is a hereditary autosomal dominant disorder caused by germline mutations in the MEN1 tumour-suppressor gene and is typically characterized by parathyroid adenomas, duodenopancreatic neuroendocrine tumors (NETs) and pituitary adenomas. Breast cancer has recently been identified as manifestation of MEN1 and female patients have early onset elevated breast cancer risk.Case report: Female pati...

Background: Assessment of response to therapy is a valid tool for dynamic risk stratification in patients with differentiated thyroid cancer (DTC). It is well documented in patients treated with total thyroidectomy and radioiodine ablation therapy (RAI), but data is still sparse regarding patients treated with lobectomy. Our study aimed to evaluate response to therapy in patients with DTC treated with lobectomy.Methods: We performed a retrospective study...

Different animal models have been used to study the postnatal effect of a prenatal exposure to an androgen excess on the female offspring. We have established a sheep model to test the hypothesis that the intrauterine environment of the PCOS mother may play a role in the etiology of the PCOS. In this regard, our sheep model for the study of PCOS has the advantage that provides mainly an androgenized milieu to the fetus in comparison to pregnant PCOS women who offers a hyperand...

Laser ablation of thyroid nodules has been used for the last two decads (Pacella et al, 2000). Surprisingly, complications are less frequent in patients treated without anesthesia, probably because eventual pain is an useful alarm symptom, leading the operator to repositioning the fiber during the procedure (Pacella et al., 2015).Material and methods: A total of 32 patients were included, without using local anesthesia. Nodules were solid, 5–72 ml v...

Introduction: In most cases, adrenal masses are non-functioning adrenocortical adenomas. On ‘Management of adrenal incidentalomas: European Society of Endocrinology Clinical Practice Guideline’ published in 2016, the experts ‘suggest against repeated hormonal work-up in patients with a normal hormonal work-up at initial evaluation unless new clinical signs of endocrine activity appear or there is worsening of comorbidities’.C...

POEMS syndrome characterized by polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes is a rare disease that usually presents in the 6th decade. We report a case of a young male in whom the presenting manifestations were mandibular mass, adrenal insufficiency and peripheral polyneuropathy. Clinical case: A thirty-three year old man from Guinea-Bissau was admitted to our hospital with asthenia, weight loss, decreased tactile sensibility with pain ...